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All have been proven to scale back the danger of vertebral fracture and some have been shown to scale back the risk of nonvertebral fractures (19). It would appear that half of the traditional doses (oestradiol 2 mg, conjugated equine oestrogen zero. All women using oestrogen for signs should be made conscious that it has a bone protecting impact (2). Cardiovascular illness Cardiovascular disease is the main cause of demise in girls worldwide, but is usually unreported in girls earlier than the age of 55. Menopausal status has been included within the Framingham danger calculator as an unbiased danger factor and a premature menopause is associated with a doubling of threat. It has been proposed that hypo-oestrogenism plays a task, but there was some conflicting data over time with regard to danger versus advantage of oestrogen replacement. Oestrogen facilitates synaptogenesis, induces growth issue manufacturing, protects in opposition to oxidative stress, and regulates neurotransmission. If the last menstrual period was more than 1 year in the past, steady combined preparations could additionally be used; in any other case sequential (continuous oestrogen with progesterone for 12�14 days per month) preparations must be commenced. After 1 yr of therapy, women on sequential preparations may change to continuous combined preparations in the event that they want to keep away from a daily bleed. Personal elements must even be thought-about: alcohol consumption and weight problems are considered to be danger elements, whereas bodily activity and breast feeding could additionally be protecting. Prescribed non-hormonal options for flushing Monoamines have been shown to play an necessary role in the control of thermoregulation, and animal studies have shown that noradrenaline acts to narrow the thermoregulatory zone. Noradrenergic stimulation of the medial preoptic space of the hypothalamus in primates causes peripheral vasodilation, warmth loss, and a drop in core temperature, similar to adjustments which occur in women throughout sizzling flushes. Clonidine is an alpha-2-adrenergic agonist licensed for use as a non-hormonal alternative for the therapy of flushing. It has been proven, in a meta-analysis of poor to honest high quality trials, to cut back sizzling flush frequency and severity at 4 weeks and at 8 weeks (24); however, adverse effects embody dry mouth, insomnia, and drowsiness. Serotonin is involved in many bodily capabilities together with temper, nervousness, sleep, sexual behaviour, and thermoregulation. Oestrogen withdrawal is associated with decreased blood serotonin levels, and short-term oestrogen therapy has been shown to increase these levels. There was an improvement in high quality of life in one study, despite no reduction in frequency of flushes, and a lower in hot flush frequency compared with placebo, in the other. Adverse effects included dry mouth, constipation, decreased appetite, nausea, and sleeplessness. Nausea sometimes improves in 2�3 days, and may be improved by titrating the dose slowly. Use of these medication in women with breast cancer utilizing tamoxifen is widespread; due to this fact, consideration must be given to potential interactions. Paroxetine is an exceptionally potent inhibitor, whereas sertraline inhibits to a lesser diploma and citalopram and escitalopram are only weak inhibitors. This was notably notable when hot flushes were related to sleep and mood disturbances. This was confirmed in another 12-week study of 304 ladies in addition to enhancements in mood, sleep problems, sexual disorders, and sweating. Alternative therapies Acupuncture is a popular type of complementary medicine used by ladies in menopause. It can be outlined because the insertion of needles into the skin and underlying tissues at particular sites, known as acupoints, for therapeutic or preventative functions. A systematic evaluation of six randomized control trials revealed only one with beneficial results of acupuncture and this trial was thought-about too small to generate reliable findings (30). Executive abstract of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. Survival patterns after oophorectomy in premenopausal girls: a population-based cohort research. Increased mortality for neurological and psychological illnesses following early bilateral oophorectomy.

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A small subset of patients with acute hepatitis could develop acute liver failure, which can be fatal. The chance of chronic an infection is inversely associated to the age of acquisition of the virus. In contrast, vertical transmission at delivery or an infection in early childhood carries a excessive threat of persistent liver an infection, which can progress to liver cirrhosis or hepatocellular carcinoma. Therefore, care is aimed at sustaining consolation and sufficient dietary steadiness, together with replacement of fluids lost from vomiting and diarrhoea. Chronic hepatitis B an infection with excessive viral load may be treated with antiviral agents such lamivudine. The vaccine is 95% effective in stopping infection and the development of persistent illness and liver cancer (131). The danger of perinatal transmission is high especially within the third trimester or postpartum interval. Hepatologists ought to be involved within the care of the pregnant woman to decide the need for and kind of antiviral therapy required throughout or after delivery. The threat of fetal hepatitis B an infection through amniocentesis is low; nonetheless, if amniocentesis is required, insertion of the needle by way of the placenta should be avoided. Neonatal an infection may be deadly or end in persistent carrier status with important lifelong risks of cirrhosis and liver most cancers. The an infection is brought on by a single-stranded virus, which is transmitted by way of contaminated blood and sexual (rare) route. Clinical analysis Acute an infection might current with loss of urge for food, nausea, vomiting, belly pain, and jaundice. During labour, invasive procedures corresponding to fetal blood sampling, fetal scalp electrode, or instrumental delivery ought to be avoided. A hepatologist ought to be involved in the care of the girl to ensure long-term hepatological follow-up. The three established routes of vertical transmission embrace in utero, during the time of delivery (commonest), and breastfeeding. Progress has also been made in lowering mother-to-child transmission and keeping moms alive. Factors which have been consistently associated with transmission embrace maternal viral load, length of membrane rupture, delivery earlier than 32 weeks, mode of delivery, and breastfeeding. Women at risk must also be screened for different sexually transmitted infections corresponding to chlamydia, syphilis, hepatitis B, gonorrhoea, and herpes. Screening for sexually transmitted infections should be performed twice during being pregnant, as soon as within the first trimester and again in the third trimester. Maternal viral load must be estimated at 36 weeks of pregnancy and a call concerning the mode of supply made. During caesarean part, the danger of transmission could also be minimized by preserving a haemostatic working subject, making an attempt to ship the fetal head with the membranes intact, and clamping the twine as early as possible (140). In women with such levels of viral load who do decline vaginal delivery, caesarean part should be carried out after 39 completed weeks. Although unlikely to confer an elevated danger of vertical transmission, intrapartum invasive procedures corresponding to fetal scalp electrode or fetal blood sampling should be avoided in girls with undetectable viral load. To prevent chorioamnionitis and perinatal transmission, labour must be expedited for all women with rupture of membranes at time period. The major antiretroviral therapies licensed for neonates are oral preparations and therefore it 226 SeCtIon 2 Fetomaternal Medicine is important to deal with the mother in order to optimize the prognosis for the preterm neonate. In the postpartum period, ladies should be advised to not breastfeed, although in resource-poor settings breastfeeding might need to proceed in the absence of legitimate options. Cases of confirmed main maternal an infection should be referred to a fetal medicine unit. Amniocentesis must be thought of from 16 weeks of gestation, as a positive result would lead to a change from remedy with spiramycin to a pyrimethamine/sulfadiazine routine (125). Spiramycin administered to the mom reduces the chance of fetal infection by 60�70% (146, 147). In proven fetal an infection with ultrasound abnormalities, the outcome could be poor together with fetal demise, neonatal demise, neurological impairment (intellectual disability, seizures, want for ventricular shunt placement), and/or chorioretinitis. In instances of confirmed fetal infection, the treatment choices embody termination of being pregnant or maternal drug therapy with a pyrimethamine/sulfadiazine routine all through being pregnant together with ultrasound surveillance for evaluation of fetal damage.

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If the diagnosis is made after the first trimester, carbimazole is probably the most sensible choice. Many girls with autoimmune hyperthyroidism find that their illness improves in pregnancy and in some the dose of antithyroid drugs could additionally be decreased or even stopped. This is because the medication will clear from the neonatal circulation rapidly, but the maternal antibodies will stay for roughly three months. As a consequence, you will need to contain the neonatologists in early fetal assessment. It must be thought-about in girls with other autoimmune diseases, particularly in these with unexplained lethargy, nausea, vomiting, hypotension or hyponatraemia. Replacement doses of hydrocortisone are often given, with larger doses within the morning, and this ought to be decided in collaboration with an endocrinologist. Women with known hypoadrenalism ought to obtain further glucocorticoids at times of stress, vomiting, and to cover labour. They must also be suggested to carry a steroid card and wear a medic-alert bracelet. It is caused by tumours of the pituitary or adrenal and by ingestion of extra doses of exogenous glucocorticoids. As adrenal tumours are reported to occur more commonly in being pregnant, probably a consequence of pituitary tumours influencing gonadotrophin secretion, Cushing syndrome shall be thought of under the heading of adrenal disease. However, the rules referring to issues are the same for both issues. Cushing syndrome could be difficult to diagnose in being pregnant as many signs and indicators are additionally seen in pregnant ladies, corresponding to weight achieve, striae, hypertension, glucose intolerance, and hirsutism. The condition is related to a quantity of adverse maternal and fetal outcomes (38�41). Severe hypertension may happen and impaired glucose tolerance or gestational diabetes mellitus have an result on 25% of cases. Metyrapone and ketoconazole have also been used in being pregnant with good maternal and fetal outcomes (39, 40). The presenting signs embrace sweating, headache, and palpitations and the principal signal is hypertension. The condition could also be missed because of these scientific options being attributed to pregnancy. However, the hypertension is commonly paroxysmal and in women with the classical symptoms and a suggestive history, plasma or urinary catecholamines, and metanephrines must be checked. If phaeochromocytoma remains undiagnosed, the maternal and fetal mortality may be as excessive as 50%, and that is markedly decreased with lively management (41, 42). It is essential to contain a multidisciplinary staff within the management of ladies with phaeochromocytoma, significantly to ensure coordinated plans for delivery. The most necessary therapy is to begin an alpha-adrenoreceptor blocker, and the most generally used drug is phenoxybenzamine. Once alpha-blockade has been achieved, some women require betablockade, but this must not be commenced before alpha-blockade has been achieved. Timing of surgical procedure varies in several research, with reviews of adrenalectomy in the course of the first 24 weeks of pregnancy, usually by a laparoscopic strategy. Surgery can be efficiently achieved at the time of supply or postpartum, offering enough alpha-blockade has been achieved (43, 44). It is essential that a team together with intensive care physicians, obstetric anaesthetists, endocrinologists, obstetricians, and midwives are involved with peripartum care. Primary aldosteronism Primary aldosteronism, also referred to as Conn syndrome, is caused by an aldosterone-producing tumour of the adrenal. The typical presenting features are hypertension and hypokalaemic alkalosis as a outcome of autonomous production of aldosterone and secondary renin suppression (45). The commonest administration strategy during being pregnant is to use potassium dietary supplements and antihypertensive medicine with deferral of surgery until after delivery. Pituitary/hypothalamic disease Prolactinoma and different pituitary tumours Prolactinomas are the most typical hormone-secreting tumours. They happen in women of reproductive age, and affected women incessantly have menstrual irregularity, lowered fertility, and galactorrhoea. Large tumours may current with headache and visual symptoms secondary to compression of the optic chiasm.

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Unlike in higher-income international locations, education in women is proportionately associated to the prevalence of obesity within the lower-middle-income nations (20). Geographical elements similar to shortened distance to walk during activities of every day residing in high-income international locations and consequently decreased power expenditure perpetuate the problem (18). Urban areas are vulnerable to the provision of meals 24 hours a day and a cultural shift to a extra sedentary lifestyle with computers and tv, which additionally perpetuate the problem. Global markets saturated with high-calorie-density foods have led to a change in meals consumption together with the fast-food marketplace allowing 24-hour access to food. Interestingly in evaluating physique weight in ladies with males, the former intercourse is influenced more by nationality, race-ethnicity, and socioeconomic status in comparison to males. This means that a better link exists between physique weight and social and cultural roles in ladies compared to men (19). Syndromes similar to trisomy 21, Prader�Willi, and Beckwith�Wiedemann are comparatively uncommon as a reason for weight problems. Research into the aetiology of widespread weight problems is fierce, nonetheless; genetic susceptibility is complicated by the flexibility of environmental change to alter gene expression by mechanisms such as methylation (22). The hypothalamus regulates vitality homeostasis through integrating neural, hormonal, and metabolic indicators from peripheral and central nervous techniques, endocrine glands, including adipocytes, and blood metabolites similar to glucose and fatty acids (23). Congenital or acquired causes of dysregulation in any of these pathways have the potential to trigger the buildup of extra power as lipids. Linkage evaluation has revealed single gene disorders as a cause for weight problems with mutations in genes such because the leptin-encoding gene, the leptin receptor gene, and pro-opiomelanocortin. This would mean a mean difference of seven kg between two individuals of similar height/ethnicity/age (14). Effect of weight problems in childhood and adolescence There is growing evidence to associate maternal prepregnancy obesity with an elevated risk of obesity and cardiometabolic threat elements within the offspring (25). Prepregnancy maternal weight problems is related to a better probability of weight problems in kids at the age of three years (26). This affiliation is independent of genetic and environmental components shared by mom and youngster (28). Maternal obesity can be associated with a danger of developmental delay and autism spectrum disorder in early childhood (29). There is also rising proof that extreme pregnancy weight gain as outlined by the American Institute of Medicine is associated in offspring with weight problems and an opposed cardiometabolic profile (25, 30, 31). The latter measures included raised C-reactive protein, systolic blood pressure, and lower high-density lipoprotein stage. These antagonistic metabolic profiles along with an increased danger of obstructive sleep apnoea in overweight adolescents are related to an increased cardiovascular threat in adults (32). The onset of puberty has lowered over the past one hundred fifty years from roughly 14 years of age to eleven. The components influencing menarche are properly characterized including genetic, hormonal, psychological, and socioeconomic factors. However, this drop in age in ladies has additionally coincided with the rise in obesity seen in the Western world. In the United States, non-Hispanic black ladies had been more obese (53%) than Mexican American ladies (48%) but considerably extra overweight than nonHispanic white girls (36%). This ethnic influence was not seen in males of the same age group (40�59 years) (19). In 2004 within the United Kingdom, it was noted that significantly more men and women from a Caribbean or Irish ethnicity have been obese when compared to the final population (21). Women of Chinese and Bangladeshi descent had the bottom prevalence of obesity however black African women had a few of the highest. Genetics There is evidence that obesity is more widespread in genetically vulnerable individuals. Other problems may be exacerbated in adolescence for obese kids such as psychological melancholy, anxiety, body picture disorder, and negative shallowness, particularly in women. This dysfunction impacts 5�10% of women and is often diagnosed with two of the following three parameters: hyperandrogenism, continual anovulation, and polycystic ovaries on ultrasonography.

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Automated blood gasoline analysis is carried out and administration depends on the clinical situation in addition to the absolute values of the scalp pH and base excess. Further abnormalities are recognized by the options of increasing depth and period of decelerations, discount of the inter deceleration intervals, rise in the baseline fee, and discount within the baseline variability. The time taken to take a fetal blood sample needs to be thought-about when planning repeat samples. The scientific context of the labour should always be considered together with parity, progress, stage of labour, and maternal wishes. This is because induced accelerations by stimulation are nearly at all times associated with non-acidotic scalp pH values. Fetal lactate measurement has been proposed as an various to scalp pH because the lactate ranges mirror anaerobic respiration and thus tissue hypoxia and metabolic acidosis. A randomized Swedish examine found that scalp pH and lactate have been no totally different in diagnosing fetal acidosis compared with pH and base excess however lactate sampling had lower failure charges (1. Although passage of meconium may be a perform of fetal maturity, it can additionally point out possible fetal compromise. Use of prostaglandin and fetal infection are additionally associated with the passage of meconium. In the presence of meconium, the fetal scalp pH result may be a less dependable indicator of poor fetal situation than is fetal oximetry. As a part of ongoing assessment in labour, the presence or absence of great meconium ought to be clearly documented. The vibroacoustic stimulation test makes use of an artificial larynx placed closed to the maternal abdominal wall to startle and get up the fetus. A meta-analysis assessed the performance of stimulation exams for the prediction of intrapartum fetal acidaemia. Monitoring requires rupture of the membranes and application of a fetal scalp electrode and a maternal pores and skin reference electrode. The outcomes confirmed a big reduction in severe metabolic acidosis and neonatal encephalopathy. This has led to the event of fetal pulse oximetry strategies to allow assessment of fetal oxygenation as a marker for fetal acidosis. An oximeter probe is passed transcervically and positioned in opposition to the fetal scalp or side of the face. Deoxygenated and oxygenated haemoglobin absorb gentle at totally different wavelengths and by utilizing normal curves the oximeter is ready to decide the fetal oxygen saturation. Several factors corresponding to sensor-to-skin contact, uterine contractions, fetal hair, and caput succedaneum may influence the efficiency and use of pulse oximetry. Other indicators including a low Apgar score at birth have been shown to be subjective and poor predictors of long-term neurological outcomes. Umbilical twine arterial blood fuel analysis at birth has emerged as an necessary method, used to help or refute a analysis of intrapartum asphyxia. This can occur in a standard labour with uterine contractions and the vast majority of fetuses can cope nicely with such episodes for long durations of time without harm. If hypoxia continues for extended periods, the fetus switches to anaerobic metabolism to create vitality and metabolic acidosis begins growing. In fetuses with compromised reserves corresponding to preterm or growth-restricted fetuses, metabolic acidosis occurs earlier. This results in important organ injury which may cause brain damage or fetal demise in utero. The nature of asphyxia can determine the type of mind injury and the neurological outcome as described by Myers in 1975 (32): 1. In the antenatal period the fetus will cope for a big period of time by redistribution of the blood flow to very important organs, discount in development or exercise, and buffering towards lactic acid. Surveillance with Doppler ultrasound can detect the point the place decompensation is in all probability going in order that delivery can be beneficial. It may be notably worsened in conditions such as oligohydramnios or prolonged pregnancies. Hypoxic insults that are gradual in onset and protracted over time enable the fetus to make homeostatic diversifications.

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In this research, the incidence of neonatal seizures was higher within the intermittent auscultation group but short-term and long-term neurological and developmental outcomes have been related in each groups. Friedman proposed that, within the energetic section of the first stage of labour, cervical dilatation ought to progress at the rate of no much less than 1 cm/ hour (2). This represented the lower tenth centile of the rate of cervical dilatation in a cohort of spontaneously labouring nulliparous ladies. Proponents of amniotomy argue that this permits visualization of the color of the amniotic fluid which, if clear, is a hallmark of the healthy fetus. There can also be a modest shortening of the length of labour following amniotomy (8). This partogram was an try and utilize midwives efficiently in a hospital where docs have been briefly provide. The medical protocol stipulated that ladies can be transferred from a peripheral unit to a central unit if progress of cervical dilatation crossed the alert line. If progress was further slowed such that it crossed the motion line, an intervention such as amniotomy and/or oxytocin infusion for augmentation of labour can be introduced. These simplified versions omit a latent part on the idea that women in spontaneous labour usually current within the lively phase of labour. Research into whether or not a partogram reduces the caesarean part rate or improves maternal and neonatal outcomes has largely yielded divided results. Conversely, a Cochrane evaluation showed no differences in clinical outcomes with or with out partogram use (5). Other modifications within the partogram include using a 2-hour or 3-hour motion line as opposed to the original 4-hour motion line. Using an motion line with a shorter length results in extra ladies receiving interventions similar to amniotomy or augmentation with oxytocin (5). The partogram additionally allows for systematic documentation of labour particulars in addition to maternal and fetal parameters which can decrease omissions. An upright or squatting place through the second stage is also associated with a reduction in need for this intervention. A coverage of restricted versus liberal use of an episiotomy is proven to cut back the risk of severe perineal harm (11). An episiotomy is more commonly carried out when a big baby is suspected, in the presence of malposition of the fetal head and through operative vaginal supply with the forceps or ventouse. If an episiotomy is performed, a mediolateral episiotomy is much less prone to be associated with obstetric anal sphincter injuries than a midline episiotomy (12). Shortening muscle fibres in the myometrium end in a reduction in the surface area underlying the placenta. Modified partograph accommodates no latent phase and is only plotted as soon as lively labour begins. Active management of third stage refers to administration of a uterotonic, controlled twine traction, and uterine massage. Both preparations present similar efficacy in decreasing postpartum haemorrhage but the mixture of oxytocin and ergometrine is associated with a higher incidence of hypertension as properly as nausea and retching. Delayed clamping of the umbilical twine refers to the apply of occluding the umbilical wire between 1 and three minutes following supply and not instantly after. Evidence exhibits that this practice is helpful as a end result of it reduces neonatal anaemia and reduces the prevalence of iron deficiency in the infant at 4 months (14). Hence, managed wire traction can safely be delayed with out leading to an increase in postpartum blood loss (15). The minimal acceptable price of progress for the lively part of the first stage of labour was defined by Friedman as 1 cm/hour in nulliparous women and 1. This standard has extra just lately been challenged with the suggestion that ordinary labour progresses somewhat slower. An abnormal first stage of labour can essentially be categorised into the next three classes: 1.

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Obstetric care in lowresource settings: what, who, and tips on how to overcome challenges to scale up Antenatal betamethasone and incidence of neonatal respiratory misery after elective caesarean section: pragmatic randomised trial. Breastfeeding after cesarean delivery: a systematic evaluate and meta-analysis of world literature. The long-term effects of delivery by caesarean section: the case for a randomised controlled trial. Delivery by caesarean section and threat of obesity in preschool age children: a potential cohort examine. Caesarean section is associated with an increased danger of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies. A meta-analysis of the association between Caesarean section and childhood bronchial asthma. Stillbirths, toddler and childhood deaths occurring annually in England and Wales, and associated threat factors. Global, regional, and national causes of child mortality in 2000�13, with projections to inform post-2015 priorities: an up to date systematic evaluation. The Inequalities in Infant Mortality Project Briefing Paper four: the Contribution of Congenital Anomalies to Infant Mortality. Presentation of congenital heart disease in infancy: implications for routine examination. Pulse oximetry screening for crucial congenital heart defects in asymptomatic new child babies: a systematic evaluate and meta-analysis. Effect of timing of umbilical twine clamping and different methods to affect placental transfusion at preterm start on maternal and toddler outcomes. Timing of umbilical wire clamping after birth for optimizing placental transfusion. Andersson O, Lindquist B, Lindgren M, Stjernqvist K, Domell�f M, Hellstr�m-Westas L. Burden of endemic health-care-associated infection in developing countries: systematic evaluation and meta-analysis. Resuscitation of new child infants with 21% or 100 percent oxygen: an updated systematic evaluate and meta-analysis. Preterm meconium staining of the amniotic fluid: associated findings and risk of antagonistic clinical outcome. Oropharyngeal and nasopharyngeal suctioning of meconiumstained neonates earlier than delivery of their shoulders: multicentre, randomised controlled trial. Delivery room management of the apparently vigorous meconium-stained neonate: results of the multicenter, worldwide collaborative trial. Increasing ambient working theatre temperature and wrapping in polyethylene improves admission temperature in premature infants. Plastic bags for prevention of hypothermia in preterm and low birth weight infants. The effect of coverings, including plastic luggage and wraps, on mortality and morbidity in preterm and full-term neonates. Donor breast milk versus toddler formula for preterm infants: systematic review and meta-analysis. Management of hyperbilirubinemia within the newborn toddler 35 or extra weeks of gestation [published correction seems in Pediatrics 2004;114:1138]. Five- and 10-year survival charges after surgery for biliary atresia: a report from the Japanese Biliary Atresia Registry. Therapeutic hypothermia for neonatal encephalopathy in low- and middle-income international locations: a systematic evaluation and meta-analysis. Research ethics committee decision-making in relation to an efficient neonatal trial. Miscarriage and recurrent miscarriage 477 Vikram Sinai Talaulikar and Mushi Matjila 39. Menopause 576 Jenifer Sassarini and Mary Ann Lumsden 38 Miscarriage and recurrent miscarriage Vikram Sinai Talaulikar and Mushi Matjila Miscarriage Definition Miscarriage is outlined as the spontaneous lack of pregnancy earlier than the age of fetal viability. Epidemiology Early miscarriage is amongst the commonest problems of pregnancy affecting up to 20% of scientific pregnancies (confirmed by ultrasound scan) and early being pregnant loss is liable for about 50,000 inpatient admissions in the United Kingdom every year (1). The chance of a subsequent profitable pregnancy following one early miscarriage is over 95% and in girls with three consecutive miscarriages is over 70% (2).

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Abbas, 23 years: Forceps to aftercoming head Grasping the fetal head with a pair of forceps correctly can ensure the top flexion during the descent process.

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